Immunotherapy In Cancer

 Understanding Immunotherapy

Immunotherapy is a type of cancer treatment that boosts the body’s natural defenses to fight the cancer. It uses substances made by the body or in a laboratory to improve or restore immune system function.

It is the “treatment of disease by inducing, enhancing, or suppressing an immune response”. Immunotherapy designed to elicit or amplify an immune response are classified as activation immunotherapy, while immunotherapy that reduce or suppress are classified as suppression immunotherapy.

Immunotherapy is a type of biological therapy. Biological therapy is a type of treatment that uses substances made from living organisms to treat cancer.

This method has been widely adopted in oncology, particularly in cases that fail to respond to other treatment.

Immunotherapy often employs substances called biological response modifiers (BRM). The body normally produces low levels of BRM in response to infection and disease. Large amounts of BRM can be made in the laboratory to treat cancer, rheumatoid arthritis, and other diseas

Cancer Basis

Cancer is a group of more than 100 different diseases. It can develop almost anywhere in the body.

Cancer Beginning:

Cells are the basic units that make up the human body. Cells grow and divide to make new cells as the body needs them. Usually, when cells get too old or damaged they die. Then new cells take their place.

But, Cancer begins when genetic changes impair this orderly process. Cells start to grow uncontrollably. These cells may form a mass called a tumor. A cancerous tumor is malignant, meaning it can grow and spread to other parts of the body. A benign tumor means the tumor can grow but will not spread.

Some types of cancer do not form a tumor. These include leukemia, most types of lymphoma, and myeloma.

 

 

Types of Cancer:

Four main types of cancer are:

  1. Carcinomas
  2. Sarcomas
  3. Leukemia
  4. Lymphomas

Cancer & Genes Mutation

Genes are found in the DNA in each cell that makes up your body. They control how the cell functions, including how quickly it grows, how often it divides, and how long it lives. Genes control how your cells work by making proteins that have specific functions and act as messengers for the cell.

There are two basic types of genetic mutations:

Acquired mutations are the most common cause of cancer. They are not passed from parent to child.

Germline mutations which are less common are passed directly from a parent to a child. In these situations, the mutation can be found in every cell of a person’s body.

Mutations happen often and the human body is normally able to correct most of them. Depending on where in the gene the change occurs, a mutation may be beneficial, harmful, or make no difference at all. So, one mutation alone is unlikely to lead to cancer. Usually, it takes multiple mutations over a lifetime to cause cancer.

     Cancer Vaccines

Vaccines, also called vaccinations, are medicines that help protect the body from disease. They help train the immune system to recognize and destroy harmful substances. There are 2 types of cancer vaccines:

Prevention vaccines &Treatment vaccines

Doctors give prevention vaccines to healthy people to keep certain cancers from developing.

There are 2 types of cancer prevention vaccines

HPV vaccine: The vaccine protects against the human papillomavirus (HPV). If the virus is long-lasting, it can cause some types of cancer.

Hepatitis B vaccine: The vaccine prevents hepatitis B virus  infection. Long-lasting infection  can cause liver cancer

Cancer treatment vaccines, also called therapeutic vaccines, are a type of immunotherapy. The vaccines work to boost the body’s natural defenses to fight a cancer. Doctors give treatment vaccines to people already diagnosed with cancer.

  Types of Immunotherapy

Different types of immunotherapy are used to treat cancer, which include:

Monoclonal antibodies: They are drugs that are designed to bind to specific targets in the body. They can cause an immune response that destroys cancer cells.

Adoptive cell transfer: It which is a treatment that attempts to boost the natural ability of the T cells to fight cancer. T cells are a type of white blood cell and part of the immune system.

Cytokines: They are proteins that are made by your body’s cells. They play important roles in the body’s normal immune responses and also in the immune system’s ability to respond to cancer. The two main types of cytokines used to treat cancer are called interferons and interleukin.

Advantages of Immunotherapy

Many reasons why doctor think immunotherapy’s is a good choice,

Immunotherapy may work when other treatments don’t. Some cancers (like skin cancer) don’t respond well to radiation or chemotherapy but start to go away after immunotherapy.

It can help other cancer treatments work better. Other therapies like chemotherapy, may work better when one also have immunotherapy.

It causes fewer side effects than other treatments. That’s because it targets the immune system instead of all the cells in your body.

Your cancer may be less likely to return. When one have  immunotherapy, your immune system learns to go after cancer cells if they ever come back. This is called immunomemory and it could help you stay cancer-free for a longer time.

 

 Side-Effects of Immunotherapy

Just like any other medication, it also has side effects.

It can harm organ system. Some of these drugs can cause your immune system to attack organs like your heart, liver, lungs, kidneys, or intestines.

It isn’t a quick fix. It takes longer to work than other common treatments. Your cancer won’t go away quickly.

Not everyone responds. Right now, immunotherapy works for less than half the people who try it. Many people only have a partial response. Doctors aren’t sure yet why immunotherapy helps only some people.

Your body could get used to it. Over time, it may stop having an effect on the cancer cells. This means that even if it has a good response at first, tumor could start to grow again.

Some types of immunotherapy amp up the immune system and cause Flu with fever, chills, and fatigue. Can even cause swelling, weight gain, stuffy head and diarrhea. They could make you more likely to get an infection. Or they could affect your nerves or raise your chance of having blood cl

Methods & Drugs

Different forms of immunotherapy may be given in different ways, which includes:

Intravenous (IV): The immunotherapy goes directly into a vein.

Oral: The immunotherapy comes in pills or capsules that you swallow.

Topical: The immunotherapy comes in a cream that you rub onto your skin. This type of immunotherapy can be used for very early skin cancer.

Intravesical: The immunotherapy goes directly into the bladder.

Immunomodulators

Iummnomodulators is a chemical agent that modifies the immune response or the functioning of the immune system (as by the stimulation of antibody formation or the inhibition of white blood cell activity)

It weakens or suppresses the immune system.

They are used for inflammatory bowel disease (IBD) that has not responded to other treatments and can be controlled only with long-term use.

Side-Effects of Immunomodulators

Trouble breathing

Swelling of face,

or lips,

or tongue,

or throat.

Green chemistry :A New Route TO Protection Of Environment

GREEN CHEMISTRY  is   a program of developing new chemical products and chemical processes or making improvements in the already existing compounds and processes so as to make them less harmful to human death and environment. Green chemistry uses the database information about the toxic and hazardous properties of certain in order to fully evaluate their positive and negative impact. The non  availability of such data in the previous years posed problems to the chemists for evaluating consequences of the chemical substance being  synthesis and green chemistry tries to find the solution of these problems.

FATHER Of Green  CHEMISTRY:

PAUL.T.ANASTAS (American) the father of green chemistry. They for the first time in 1991 coined the term green chemistry. Recently Paul T. Anastasio the Director of Yale University’s  for Green Chemistry and Green Engineering.   15 years ago in 1990 the concept of green chemistry was established at the Environment Protection Agency . It was a response to the Pollution Prevention Act of 1990

Introduction:

When we start talking about GREEN CHEMISTRY many of us relate Green chemistry to the branch of science involving plants.  However, it is nothing to do with the chemistry of plants. In fact, it relate to the program of alternative synthetic pathways for prevention of environmental pollution. The expression green chemistry was used by scientists in 1902 after the formation of Pollution Prevention Act 1990.

GREEN CHEMISTRY is simply a way of utilizing the existing knowledge and principles of Chemistry  and other sciences to reduce the  harmful impact on environment due to the compounds.

GREEN CHEMISTRY

 

HISTORY :

In the period of 1990’s a variety of ideas and research efforts (such as atom economy and catalysis ) emerged Green Chemistry .

Green chemistry is also known as  “clean” and “sustainable” chemistry .

In 1962 a book Silent spring was written by Rachel Carson . It was a scientific book  it talked about the devastation that certain chemical had on local ecosystem. The book served as wake up call for thee Public  as well as the scientist and inspired the Morgen environmental movement . After this the congress noticed the importance and passed the National Environment Policy Act  in 1969. This was The  first step taken for the environment.

12 Principles of Green Chemistry

  • Prevention

“ It is better to prevent waste than to treat or clean up waste after it is formed”.

  • Atom Economy

“Synthetic method should be designed to maximize the incorporation of all materials used in process into the final products”.

  • Less Hazardous Chemical Syntheses

Whenever practicable, synthetic methodologies should be designed to use and generate substance that litter or no toxicity to human health and environment”

  • Designing Safer Chemicals

Chemical products should be designed to preserve Efficacy of function while reducing toxicity”.

  • Safer Solvents and Auxiliaries

“ The use of auxiliary substance should be made unnecessary where possible and innocuous when used”.

  • Reduce Derivatives

Reduce derivatives unnecessary derivatives should be avoided whenever possible”.

  • Catalysis

“Catalytic reagents are superior to chemical reagents”

Use of a catalyst facilities transformation without the catalyst being consumed in the reaction and without incorporated in the final product.

  • Design for Degradation

“Chemical products should be designed so that at the end of their function they do not persist in the environment and break down into innocuous degradation products”.

  • Real-time analysis for Pollution Prevention

 

“ Analytical methodologies need to be further developed to allow for real-time, in process monitoring and control prior to the formation of hazardous substance”.

“Checking the Progress of chemical reaction as it happens”.

  • Inherently Safer Chemistry for Accident Prevention

“Substance and the form of a substance used in a chemical process should be chosen to low  potential for chemical accidents, including releases explosions, and fires”.

Design for Energy Efficiency

“Energy requirements should be recognized for their environmental and economic impacts and should be minimized. Synthetic method should be conducted at ambient temperature and pressure”.

Use of Renewable Feed stocks

“ A raw material or feed stock are often made from agricultural products are the waste of the other processes depleting feed stock are made from fossil fuels or are mined.

 APPLICATION OF GREEN CHEMISTRY (Tulsa):

Green Chemistry In industry

  • Development of dense-phase carbon dioxide.

Dense-phase Carbon dioxide has been characteristics. This super critical Carbon dioxide is wonderful material which has the ability to clean everything from the plutonium pits to semiconductor wafer as well as clothes. It can also be used as recyclable solvent and finds number of applications in food industry. Future possible uses of the Carbon dioxide  include making cement stronger and also in reducing pollution emission from coal plants.

  • Development of fuel cells for cellular phones which can last full life time of thee phones. These cells are based on methanol-oxygen fuels.
  • Development of new method for synthesizing ibuprofen in 99 Percent yield, avoiding the use of large quantities of solvents and waste associated with traditional methods.
  • Development of a safer marine  compound sea-nine that degrades more rapidly than organised  which persist in Marin environment and cause pollution problems.
  • Development of a method for catalytic hydrogenation of diethanolamine. The new Friendly herbicide in a less dangerous way. This technology represents a major break through because it avoids the use of cyanide  and formaldehyde.

 

application of green chemistry

GREEN CHEMISTRY IN Daily  LIFE:

  • Dry Cleaning of clothes

1,1,2,2-Tetrachloroethane was earlier used as solvent for dry cleaning clothes. The compound contaminates the ground water and is also a suspected carcinogen. Now a days, Carbon dioxide  along with suitable detergent is used for dry cleaning in place of 1,1,2,2-Tetrachloroethane Replacement of hydrogenated solvent  Carbon dioxide will result in less harm of ground water.

  • Bleaching of paper and clothes

Chlorine gas was used earlier for bleaching of the paper. These days, hydrogen peroxide with some Suitable  catalyst is used. Hydrogen peroxide is also used for the purpose of bleaching of clothes in the Laundry processes, which gives better results and makes use of lesser amount of water.

GREEN CHEMISTRY IN Agriculture (BRAZILIAN):

Agriculture is the one of the most important things for humans.It  plays an important role in the field of agriculture. Green chemistry principle are mostly related to the manufacturing part of the agriculture the pesticide, fertilizers should be non-toxic and should not harm the agriculture by any means And they also not harm humans and environment. There are many ways by which agriculture can be protected by green chemistry like:

  • Minimise the risk of pesticides
  • Using suitable fertilizer
  • Maintain the variety
  • Energy efficiency in the chemicals industry

Barriers of GREEN CHEMISTRY IN INDIA:

 1: Availability of green technologies

2: Scale-up and commercial

3: Connecting green chemistry solution providers to industry

4:Understanding of basics of green principle

5: Green chemistry is costly, complex and not viable for SME?

6: Regulatory hurdles

Future aspects of green chemistry:

As we know green chemistry plays very important role for environment. In India present day also there are places where green chemistry should be applied but due to many reasons . In future

Green chemistry should be used there are  many of the reasons 

  • Results in healthier living conditions
  • Is economical and profitable
  • Encourages creativity in the world of chemistry
  • Is healthy for the environment.